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SOX2 gene amplification and protein overexpression are ...
1. Mod Pathol. 2011 Jul;24(7):944-53. doi: 10.1038/modpathol.2011.49. Epub 2011 Apr 1. SOX2 gene amplification and protein overexpression are associated with better ...

Notes on gene amplification - Columbia University
Notes on gene amplification Biol.G4054y ...

HER2 Gene Amplification in Breast Cancer - American ...
HER2 Gene Amplification in Breast Cancer A Rogues’ Gallery of Challenging Diagnostic Cases: UKNEQAS Interpretation Guidelines and Research Recommendations

Excellent outcome with reduced treatment for infants with ...
1. J Clin Oncol. 2009 Mar 1;27(7):1034-40. doi: 10.1200/JCO.2008.17.5877. Epub 2009 Jan 26. Excellent outcome with reduced treatment for infants with disseminated ...

Pharmaceutical PCR & Gene Amplification Glossary & taxonomy
You are here Biopharmaceutical/ Genomic glossary homepage/Search > Technologies > Pharmaceuticals --Gene amplification & PCR Polymerase Chain Reaction

Activating HER2 Mutations in HER2 Gene Amplification ...
Identification of HER2 Somatic Mutations in Patients without HER2 Gene Amplification. We identified 2 breast cancer patients with HER2 somatic mutations by conducting ...

Modern Pathology - SOX2 gene amplification and protein ...
SOX2 Amplification FISH Assay. To assess for SOX2 amplification status at the chromosomal level on tissue microarray slides, we applied the same two-color interphase ...

Determination of HER2 Gene Amplification by Chromogenic In ...
Top INTRODUCTION. HER2 gene amplification or HER2 protein overexpression has been identified in 10–34% of invasive breast cancers according to a series of 52 ...

The RMM Blog - Rapid Microbiology and Rapid ...
The United Nations World Health Organization (WHO) today announced that it has approved for use a rapid diagnostic test kit for Ebola that can provide results in 15 ...

Her 2 - The Doctor's Doctor
Accurate determination of HER-2 status is important in the management of patients with breast cancer, especially in determining their eligibility for trastuzumab therapy.



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       *** News Filter: "Gene-Amplification"





Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies ...
PR Newswire (press release)
Immunohistochemistry and gene amplification identified low ERCC1 (64%), low TUBB3 (74%) and high TOPO1 (51%) as targets for platinum-based therapies, taxanes, and topotecan, respectively. Mutational analysis revealed high mutation rates in PIK3CA, ...
Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling ...Virtual Press Office (press release)

all 11 news articles »

Energy stress tames the Hippo pathway
It is therefore not surprising that many cancers express higher levels of YAP or TAZ, which seems to originate through several mechanisms, including gene amplification. Mouse tumour models indicate that even a twofold reduction in the gene dosage of ...

Howard Hughes Medical Institute

Rare Genetic Mutations May Make Influenza Life-Threatening for Some
Howard Hughes Medical Institute
They found two mutations that affected the gene for IRF7, a protein that switches on target genes to amplify the production of antiviral molecules called interferons. “In any cell in the body, when a virus infects the cell, IRF7 is going to be ...
Single Gene May Explain Why The Flu Can Kill: Kids With Genetic Mutations At ...Medical Daily

all 39 news articles »

Involvement of tumor suppressors PTEN and p53 in the formation of multiple ...
Chromosomal amplifications of the 12q13–15 region, which include the MDM2, CDK4 and HMGA2 genes, among others, are a characteristic feature of LPSs.4, 5, 6 MDM2 amplification occurs in several cancers and is thus of importance in tumorigenesis.7 ...

SIP metagenomics identifies uncultivated Methylophilaceae as dimethylsulphide ...
Microbial communities involved in DMS degradation were analysed by denaturing gradient gel electrophoresis, high-throughput sequencing of SIP gradient fractions and metagenomic sequencing of phi29-amplified community DNA. Labelling patterns of time ...

Metatranscriptomic census of active protists in soils
Ciliates on the contrary are highly overrepresented because of their shorter SSU rRNA sequences that ease amplification, and the presence of extremely high SSU rRNA gene copy numbers (Gong et al., 2013). Most of these obstacles are avoided when ...

Activation of sirtuin 1 as therapy for the peroxisomal disease ...
Quantification of mtDNA was referred to nDNA as determined by the amplification of the intronless mouse nuclear gene C/EBPα (Mm00514283).24 Each sample was run in duplicate, and the mean value of the duplicate was used to calculate the mtDNA ...



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