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Gene amplification - definition of gene amplification by ...
The mere detection of EGFR protein expression or gene amplification on primary tumor cells has not been successful as a reliable predictor (2-4).

Gene Amplification: An Example of Accelerated Evolution in ...
Proc. Natl. Acad. Sci. USA Vol. 82, pp. 7015-7019, October 1985 Genetics Gene amplification: An example of accelerated evolution in

Bacterial gene amplification: implications for the ...
Gene amplification is found in all three kingdoms of life and is important both from a fundamental evolutionary perspective 1, 2, 3 and in medical genetics as an ...

Chromogenic in situ hybridization - Wikipedia, the free ...
Chromogenic in situ hybridization (CISH) is a cytogenetic technique that combines the chromogenic signal detection method of immunohistochemistry (IHC) techniques ...

Fibroblast Growth Factor Receptor 1 Gene Amplification Is ...
1. J Clin Oncol. 2013 Feb 20;31(6):731-7. doi: 10.1200/JCO.2012.43.8622. Epub 2012 Nov 26. Fibroblast growth factor receptor 1 gene amplification is associated with ...

Gene amplification of ribosomal protein S6 kinase-1 and -2 ...
1. Anticancer Res. 2013 Feb;33(2):469-75. Gene amplification of ribosomal protein S6 kinase-1 and -2 in gastric cancer. Yoshida S(1), Matsumoto K, Arao T, Taniguchi H ...

Estrogen receptor alpha (: ESR1: ) gene amplification is ...
Abstract. Using an Affymetrix 10K SNP array to screen for gene copy number changes in breast cancer, we detected a single-gene amplification of the ESR1 gene, which ...

MedTerms - Alpha Index, G listing - Medical Dictionary
Online Medical Dictionary and glossary with medical definitions, g listing.

NCI Dictionary of Cancer Terms - National Cancer Institute
HER2/neu A protein involved in normal cell growth. It is found on some types of cancer cells, including breast and ovarian. Cancer cells removed from the body may be ...

Neuroblastoma Treatment - National Cancer Institute
Expert-reviewed information summary about the treatment of childhood neuroblastoma.

 

 

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       *** News Filter: "Gene-Amplification"

 

 

 

                  

Breast cancer: The debate over post-mastectomy radiotherapy should continue
Nature.com
After the era in which the clinical trials included in the EBCTCG meta-analysis were designed, scientific advances have identified new clinically relevant subgroups of breast cancer that are distinguished by differing gene-expression patterns and are ...


Genetic Engineering & Biotechnology News

Proofing Genome Edits
Genetic Engineering & Biotechnology News
... of clones. We have developed several methods that enable fast, sensitive, and reliable detection and analysis of indels (insertions and deletions) induced by precise gene targeting. ... (B) PCR amplification from cell extracts lysed from various ...


HIV-1 infections with multiple founders are associated with higher viral loads ...
Nature.com
More recently, large studies have sought to derive HIV-1 sequences through single-genome amplification (SGA) from samples collected in acute or early HIV-1 infection to better define the viruses that are establishing the HIV-1 infection; as such, ... a ...

and more »


Nature.com

A novel mutation in the β-spectrin gene causes the activation of a cryptic 5 ...
Nature.com
The analysis of genes involved in hereditary spherocytosis, by next-generation sequencing in two patients with clinical diagnosis of the disease, showed the presence of the c.1795+1G>A mutation in the SPTB gene. cDNA amplification then revealed the ...


Nature.com

Octanoylation of early intermediates of mycobacterial methylglucose ...
Nature.com
... end architecture and about subsequent biosynthetic steps. Functional characterization of this unique octanoyltransferase, whose gene has been proposed to be essential for M. tuberculosis growth, adds new insights into a vital mycobacterial pathway ...


Medical Xpress

Researchers Develop LR-PCR, NGS Combination Method to Detect PMS2 Gene Mutations
GenomeWeb
Aiming to improve the detection accuracy for PMS2 gene mutations, the researchers performed multiplex ligation-dependent probe amplification (MLPA), target capture next-generation sequencing, and long-range PCR (LR-PCR). They performed their ...
Public Release: 27-Aug-2015 New strategy improves detection of genetic ...EurekAlert (press release)

all 5 news articles »


Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer ...
Nature.com
Pak1 is frequently overexpressed and/or hyperactivated in different human cancers, including human breast, ovary, prostate and brain cancer, due to amplification of the PAK1 gene in an 11q13 amplicon. Genetic or pharmacological inactivation of Pak1 has ...

 

 

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